Anti-24P4C12 proteins (Ha5-1(5)2.1)

Anti-24P4C12 proteins [Ha5-1(5)2.1], Recombinant, IgG kappa, Rabbit

CloneID: Ha5-1(5)2.1

Antigen Long Description: The original antibody was generated by immunizing of human γ2 producing XenoMice with RAT(E)-24P4C12 cells.

Buffer Composition: PBS only.

Specificity Statement: This antibody specifically binds to recombinant 24P4C12 expressing cells (PC3-24P4C12) and multiple cancer cell lines expressing 24P4C12.

Application Notes (Clone): This antibody was capable of binding cells expressing 24P4C12 proteins on their surface in a flow cytometric assay. This antibody can be used in the development of an antibody-drug conjugate for targeted delivery of toxins to cancerous cells. The cytotoxicity of Ha5-1(5)2.1-vcMMAE antibody-drug conjugates was evaluated in PC3 cells engineered to express 24P4C12 and it was reported that it can selectively deliver a cytotoxic drug to 24P4C12 expressing cells leading to their killing. Ha5-1(5)2.1vcMMAE also inhibited the growth of subcutaneous and orthotopically established human androgen-independent prostate cancer xenograft in SCID mice (US8309093).

• SKU: ABAAb04095-23.0-BT
• Manufacturer: Absolute Antibody
• Manufacturer SKU: Ab04095-23.0-BT
• Package Unit: 1 mg
• Quantity Unit: STK
• Reactivity: Human
• Clonality: Recombinant
• Application: Flow Cytometry
• Isotype: IgG kappa
• Host: Rabbit