CloneID: AI-K11B
Antigen Long Description: The original antibody was generated by immunizing mouse with anti-morphine antibody 3K11 conjugated with KLH.
Buffer Composition: PBS with 0.02% Proclin 300.
Available Custom Conjugation Options: AP, HRP, Fluorescein, APC, PE, Biotin Type A, Biotin Type B, Streptavidin, FluoroProbes 647H, Atto488, APC/Cy7, PE/Cy7
Specificity Statement: This antibody specifically binds anti-morphine antibody 3K11. It is an idiotypic antibody which exhibits the antigenic properties of morphine, binds to opioid receptors. When used for immunization, it induces the production of antibodies that specifically recognize morphine derivatives like 6-hemisuccinyl (GSM), 3-O-carboxymethyl (KMM) and 2-p-carboxy-phenylazomethyl (FAM) esters.
Application Notes (Clone): This antibody is capable of binding to opioid receptors on T98G human glioblastoma cells. This antibody could also recognize conjugate of mAb 3K11 - horseradish peroxidase with 6-hemisuccinyl morphine ester-BSA in an ELISA. The binding affinity of this idiotype antibody to 3K11 was determined to be Kd = 3.2 nM. When rabbits were immunized with AI-K11B antibody, they generated antibodies that were capable of recognizing all tested derivatives of morphine (RU2745374).
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