CloneID: AB3
Antigen Long Description: The original antibody was generated by immunizing BALB/c mice with human alpha-fetoprotein.
Buffer Composition: PBS only.
Chimeric Use Statement: This chimeric rabbit antibody was made using the variable domain sequences of the original Mouse IgG1 format for improved compatibility with existing reagents assays and techniques.
Uniprot Accession No.: P02771
Specificity Statement: This antibody binds human alpha-fetoprotein (AFP). AFP is made in the liver of developing babies. It binds copper, nickel, and fatty acids as well as, and bilirubin less well than, serum albumin. AFP levels in healthy adults is very low. Elevated levels of AFP in adult human blood is a marker for cancer.
Application Notes (Clone): This antibody can be used in combination with another anti-alpha fetoprotein antibody AB2 for detection of human AFP using sandwich ELISA. AB3 is used as the capture antibody and HRP labelled AB2 is used as detection antibody. This antibody was also used for the immunofluorescent staining of HepG2 hepatoma cells and immunohistochemical analysis of human liver cancer tissue (CN107022029).
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