CloneID: Eculizumab
Antigen Long Description: C5 is activated by C5 converatse into C5a, an anaphylatoxin, and C5b a component of the membrane attack complex.
Buffer Composition: PBS only.
Uniprot Accession No.: P01031
Specificity Statement: Binds human C5 centred in the MG7 domain, at an epitope spanning Lys-879 to Arg-885 (Jore et al. 2016) Polymorphisms at Arg-885 correlate with drug resistance. Eculizumab demonstrates no appreciable species cross-reactivity. It is highly species specific. with no appreciable activity against chimpanzee, baboon, rhesus or cynomologous monkey, pig, rabbit, guinea pig, or rat complement
Application Notes (Clone): This antibody inhibits activation of C5. The human Fab version (Ab00296-10.6) of this antibody was used by Jore et al. (2016, PMID: 27018802) to determine the binding site of this antibody to C5.
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