CloneID: 8B2-H6-10.7
Heavy Chain modification: Fc Silent™
Antigen Long Description: The original antibody was generated by immunizing mice with mutant calreticulin protein.
Buffer Composition: PBS only.
Chimeric Use Statement: This is a reformatted human IgG1 Fc Silent™ antibody, based on the original human IgG2a format, created for improved compatibility with existing reagents, assays and techniques.
Uniprot Accession No.: Q96L12
Specificity Statement: The antibody specifically binds to calreticulin protein.
Application Notes (Clone): The original format of the antibody was used to stain Ba/F3-MPL cells expressing the different CALR constructs for detection of the surface CALR by FACS analysis. The antibody showed specific detection of mutant CALR proteins, both del52 (Typel) and ins5 (Type2), on the surface of the respective Ba/F3 cells (EP3227341A1).
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