CloneID: AH36
Buffer Composition: PBS only.
Specificity Statement: This antibody specifically binds cocaine-amphetamine regulated transcript peptide also known as CART, which is a widely distributed neurotransmitter expressed in the central nervous systems. Studies have shown the role of CART in food intake, maintenance of bodyweight, stress control, reward and pain transmission. Repeated administration of psychostimulants enhances expression of CART peptide. Nucleus accumbal-injected CART peptide plays a positive role in the regulation of behavioral sensitization induced by psychostimulants and regulated the mesocorticolimbic dopaminergic pathway. CART peptide also exerted an inhibitory effect on psychostimulant-enhanced dopamine receptors signaling, Ca2+/calmodulin-dependent kinase signaling and crucial transcription factors expression.
Application Notes (Clone): The binding reactivity of this antibody to CART was checked using ELISA. The in-vivo administration of this antibody in mice had no effects on the normal spontaneous activities of the animal. However, when mice were given this antibody intraperitoneally before administration of cocaine, it inhibited the expression of cocaine-induced animal behavioral sensitization (CN101280016). This antibody is recommended for studies relating to treatment of drug addiction.
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