Anti-CCL2 (Carlumab)-McMMAF

Product Description: Anti-CCL2 (Carlumab)-McMMAF is an antibody-drug conjugate (ADC) consisting of the humanized anti-CCL2 (chemokine ligand 2) antibody Carlumab (HY-P99188) conjugated to the protective group maleimidocaproyl and the tubulin inhibitor MMAF (HY-15579). The ADC toxic molecule and linker part are McMMAF (HY-15578). Anti-CCL2 (Carlumab)-McMMAF induces apoptosis and can be used in cancer research[1][2].

Applications: Cancer-programmed cell death

Formula: N/A

References: [1]Fetterly GJ, et al. Utilizing pharmacokinetics/pharmacodynamics modeling to simultaneously examine free CCL2, total CCL2 and carlumab (CNTO 888) concentration time data. J Clin Pharmacol. 2013 Oct;53(10):1020-7./[2]Tai YT, et al. Novel anti-B-cell maturation antigen antibody-drug conjugate (GSK2857916) selectively induces killing of multiple myeloma. Blood. 2014 May 15;123(20):3128-38.

Molecular Weight: N/A

Research Area: Cancer

Target: Antibody-Drug Conjugates (ADCs);Apoptosis;CCR;Microtubule/Tubulin

• SKU: MEXHY-171682-0
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-171682-0
• Package Unit: Get quote
• Quantity Unit: STK