CloneID: VHHCD11b
Antigen Long Description: The original antibody was originated by immunizing a camel with recombinant DC11b.
Buffer Composition: PBS only.
Chimeric Use Statement: This is a chimeric antibody, developed from the original camelid VHH antibody, specifically engineered for enhanced compatibility with existing reagents, assays, and techniques.
Uniprot Accession No.: P05555
Specificity Statement: The antibody is specific for CD11b.
Application Notes (Clone): The original format of the antibody specifically bound to CD11b+ cells in lymph nodes and spleen by two-photon microscopy and flow cytometry analysis. 18F-labelled antibody was used for noninvasive imaging of CD11b+ cells, both in normal and in tumor-bearing mice (Rashidian et al., 2015; PMID: 25902531). The antibody was conjugated to an H-2Db -restricted immunodominant E7 epitope (an HPV tumor antigen peptide) for treatment of HPV induced cancer (Woodham et al., 2018; PMID: 29792298).
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