Target: TNF Receptor I
Clone: 55R-593
Specificity: Armenian Hamster anti-Mouse CD120A (Clone 55R-593) recognizes Mouse CD120A
Purification method: This monoclonal antibody was purified using Protein A
Antigen Distribution: Variety of cell types at low levels
Background: Tumor Necrosis Factor Receptor Type I (TNFRI) is a 55kD Type I transmembrane protein. TNFRI is expressed independently of TNFRII at low levels on a wide variety of cell types. TNFRI binds TNF-A and TNF-B (also known as LT-A). The subsequent signaling is known to be important for inducing cytolytic activity, antiviral activity, expression of manganous superoxide dismutase and intercellular adhesion molecule (ICAM), IL-6 mRNA accumulation and NF-ĸB induction. TNFRI carries an approximately 80 amino acid death domain near its carboxy terminus capable of transmitting an apoptotic signal through its interaction with TRADD (TNF Receptor I associated death domain protein). Binding of 55R-170 antibody to TNFRI has been shown to block in vitro and in vivo receptor signaling initiated by ligand binding.
Immunogen: E. coli-expressed extracellular domain of the mouse TNFRI protein
Concentration: 1.0 mg/ml
Formulation: 0.01 M phosphate buffered saline (PBS) pH 7.2, 150 mM NaCl with no carrier protein, potassium or preservatives added.
Purity: >95% by SDS-PAGE and HPLC
Endotoxin: ≤ 1.0 EU/mg as determined by the LAL method
Aggregation: Aggregation level ≤ 5%
Use: Products are for research use only. Not for use in diagnostic or therapeutic procedures.
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