CloneID: WM15
Heavy Chain modification: Fc Silent™
Antigen Long Description: The orignal antibody was raised by immunizing a mouse with human CD20.
Buffer Composition: PBS only.
Chimeric Use Statement: This is a reformatted human IgG1 Fc Silent™ antibody, based on the original human IgG1 format, created for improved compatibility with existing reagents, assays and techniques.
Uniprot Accession No.: P15144
Specificity Statement: This antibody is specific for human CD13, but its epitope is destroyed during the process of formalin fixation and paraffin embedding.
Application Notes (Clone): The original antibod was used for immunohistochemsitry on a range of human inflammatory tissue specimens. This antibody was used for flow cytometry on CD31+ CD45- endothelial cells identified with mouse anti-human FITC-CD31 (Di Matteo et al., 2011; PMID:21339174), and on he human monocytoid cell line U937 (Löhn et al., 2002; PMID:11999577). This antibody was used for an in vitro wound scratch assay on human fibroblasts, it showed a 42% decrease in cell migratory activity. This antibody was used for a proliferation assay on human fibroblasts, it showed that the antibody did not affect the proliferation of fibroblasts (Lai et al., 2010; PMID:20589526).
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