CloneID: 059-053
Heavy Chain modification: ScFv
Antigen Long Description: The original antibody was isolated by panning a phage display library against CD147.
Buffer Composition: PBS only.
Chimeric Use Statement: This is a reformatted human scFv antibody, based on the original human scFv format, created for improved compatibility with existing reagents, assays and techniques.
Uniprot Accession No.: P35613
Specificity Statement: The antibody is specific for CD147. CD147 acts as a retinal cell surface receptor for NXNL1 and plays an important role in NXNL1-mediated survival of retinal cone photoreceptors. Further, in association with glucose transporter SLC16A1/GLUT1 and NXNL1, promotes retinal cone survival by enhancing aerobic glycolysis and accelerating the entry of glucose into photoreceptors.
Application Notes (Clone): The IgG1 format of the antibody specifically bound to the cancer cells expressing CD147 (CCF-RC1, ACHN) and expresses the ADCC activity (US9388249B2).
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