Anti-CD155 (CD155.16 )

Anti-CD155 [CD155.16 ], Recombinant, IgG1 kappa, Human

CloneID: CD155.16 

Antigen Long Description: The original antibody was generated by immunizing KAC mice (KAC mouse is a genetically engineered mouse strain that expresses BAP -Biotin Accepting Peptide, sequence on constant part of kappa chain) subcutaneously with CD155-Fc fusion protein.

Buffer Composition: PBS only.

Uniprot Accession No.: P15151

Specificity Statement: This antibody binds human CD155 also called the poliovirus receptor (PVR). The binding of this antibody does not block binding of TIGIT to CD155/PVR. This protein mediates NK cell adhesion and triggers NK cell function. It also binds two NK cell receptors CD96 and CD226. CD155 is gaining more interest as a therapeutic target in the field of tumor immunology due to its prominent endogenous and immune functions.

Application Notes (Clone): This antibody was used to identify CD155 expression on U-87 MG and U-87 MG PVRhi cell lines using flow cytometry. This antibody was used in the generation of anti-CD155 -saporin and anti-CD155-diphtheria immunotoxins and were tested for its antitumor activity. Cytotoxic effect was determined by ToxiLight kit. The results suggested that the immunotoxins were successful in killing CD155 expressing tumor cells.(WO2019102456).

• SKU: ABAAb03901-10.0-BT
• Manufacturer: Absolute Antibody
• Manufacturer SKU: Ab03901-10.0-BT
• Package Unit: 1 mg
• Quantity Unit: STK
• Reactivity: Human
• Clonality: Recombinant
• Application: Flow Cytometry
• Isotype: IgG1 kappa
• Host: Human