CloneID: 1D3
Heavy Chain modification: Fc Silent™
Buffer Composition: PBS only.
Chimeric Use Statement: This is a reformatted mouse IgG2a Fc Silent™ antibody, based on the original mouse IgG2a format, created for improved compatibility with existing reagents, assays and techniques.
Uniprot Accession No.: P25918
Specificity Statement: The antibody is specific for mouse CD19.
Application Notes (Clone): The scFv fragment of the antibody was employed in the generation of a chimeric antigen receptor (CAR) which bound to CD19. Mice were administered mouse CAR-expressing cells or control cells. Anti-muCD19 CAR-T mice exhibited elevated serum IL-6 levels on day 2 after CAR-T administration, with a decrease at day 5, compared to control mice that exhibited very low or no increase in serum IL-6 levels. A20 tumor bearing mice were administered CPA and anti -mouse CD 19 CAR-T cells and evaluated for various parameters. Animals treated with CPA and anti-mouse CD 19 CAR-T cells were observed to have elevated levels of serum cytokines, as compared to controls (EP3644721A1).
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