CloneID: 2C6.9
Buffer Composition: PBS only.
Uniprot Accession No.: P56856
Specificity Statement: This antibody is specific for human claudin-18.2. Alterations in claudin expression can impair tight junction function, influence signaling pathways, and act as a tumor-promoting event in some epithelial cancers. Claudin 18.2 is overexpressed in various tumor type and is found to be a potentially important target in advanced gastric cancer.
Application Notes (Clone): This antibody can be used for the detection of human claudin 18.2. This antibody was also used in the generation of a CAR-T cell receptor. CLDN18.2 CAR-T specifically binds to tumor cells, activated 2C6.9-T-PD-1 CAR-T alleviates or eliminates immunosuppression by secreting anti-PD-1 antibodies, increasing the anti-tumor effect. 2C6.9-T can activate primary T cells and efficiently mediate the killing of tumor cells expressing CLDN18.2 by T cells and caused a significant increase in cytokine secretion (CN113754780).
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