CloneID: E1
Antigen Long Description: The original antibody was generated by immunizing mice with CHO cells stably transfected with human claudin-18.2.
Buffer Composition: PBS with 0.02% Proclin 300.
Available Custom Conjugation Options: AP, HRP, Fluorescein, APC, PE, Biotin Type A, Biotin Type B, Streptavidin, FluoroProbes 647H, Atto488, APC/Cy7, PE/Cy7
Uniprot Accession No.: P56856
Specificity Statement: This antibody is specific for human claudin-18.2 and does not cross react with claudin-18.1. Alterations in claudin expression can impair tight junction function, influence signaling pathways, and act as a tumor-promoting event in some epithelial cancers. Claudin 18.2 is overexpressed in various tumor type and is found to be a potentially important target in advanced gastric cancer.
Application Notes (Clone): The binding of this antibody to claudin-18.2 expressed on the surface of CHO cells was determined using flow cytometry (CN113321730).
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