Anti-Cocaine (15A10)

Anti-Cocaine [15A10], Recombinant, IgG1 lambda, Human

CloneID: 15A10

Antigen Long Description: The original antibody was generated by immunizing BALB/c mice with BSA conjugated transition state analogs of cocaine.

Buffer Composition: PBS only.

Specificity Statement: This antibody hydrolyzes the benzoyl ester of cocaine to form the nonpsychoactive metabolites benzoic acid and ecgonine methylester. Cocaine is a strong stimulant used clinically as a local analgesic and vasoconstrictor and illegally as a recreational drug.

Application Notes (Clone): This catalytic antibody is capable of cocaine to its non psychoactive metabolites. The rate of acceleration of the catalytic antibody was reported to be (kcat/kuncat = 2.3 × 10^4). Competitive ELISA was used for the detection of binding of this antibody to the transition-state analogue of cocaine (Yang et al., 1996). In a model of cocaine overdose, this antibody protected rats from cocaine-induced seizures and sudden death in a dose-dependent fashion; a noncatalytic anticocaine antibody did not reduce toxicity. In a model of cocaine addiction, this antibody blocked completely the reinforcing effect of cocaine in rats (PMID: 9707620).

• SKU: ABAAb03749-10.0-BT
• Manufacturer: Absolute Antibody
• Manufacturer SKU: Ab03749-10.0-BT
• Package Unit: 1 mg
• Quantity Unit: STK
• Reactivity: Various species
• Clonality: Recombinant
• Application: ELISA, In Vivo Assay
• Isotype: IgG1 lambda
• Host: Human