Anti-collagen I (AFA)

Anti-collagen I [AFA], Recombinant, IgG1 kappa, Human

CloneID: AFA

Heavy Chain modification: Fc Silent™

Antigen Long Description: The original antibody was generated by immunizing mice with α2Ct.

Buffer Composition: PBS only.

Chimeric Use Statement: This is a reformatted human IgG1 Fc Silent™ antibody, based on the original human IgA format, created for improved compatibility with existing reagents, assays and techniques.

Uniprot Accession No.: P02452

Specificity Statement: The antibody is specific for the C-terminal telopeptide region of human collagen I.

Application Notes (Clone): The original antibody could block the binding activity of the C-terminal telopeptide region of human collagen I. Biosensor assays of binding interactions of the original format and the Fab fragment of the antibody with procollagen I and the α2Ct were measured (Kd = 663pM for the original antibody and 268nM for the Fab fragment and 21pM for the original antibody and 57nM for the Fab fragment for procollagen and α2Ct respectively) (US20200048333A1).

• SKU: ABAAb04361-10.3-BT
• Manufacturer: Absolute Antibody
• Manufacturer SKU: Ab04361-10.3-BT
• Package Unit: 1 mg
• Quantity Unit: STK
• Reactivity: Human
• Clonality: Recombinant
• Application: Blocking
• Isotype: IgG1 kappa
• Host: Human