Anti-CPS-500 (18.44)

Anti-CPS-500 [18.44], Recombinant, IgM kappa, Mouse
SKU
ABAAb03424-21.0-BT
Packaging Unit
500 μg
Manufacturer
Absolute Antibody

Availability: loading...
Price is loading...
CloneID: 18.44

Antigen Long Description: The original antibody was generated by immunizing mice with whole cells of Cryptosporidium parvum.

Buffer Composition: PBS only.

Chimeric Use Statement: This reformatted mouse antibody was made using the variable domain sequences of the original Mouse IgG1 format for improved compatibility with existing reagents assays and techniques.

Specificity Statement: This antibody binds the CPS-500 antigen of sporozoites and merozoites of Cryptosporidium parvum. Cryptosporidium parvum is a coccidian parasite that infects intestinal epithelium and causes diarrheal disease in humans and other agriculturally important food animals for which specific therapy and immunoprophylaxis are unavailable. Cryptosporidiosis is self-limiting in hosts with normal immune systems; however, in neonates, the elderly, and hosts having congenital or acquired immunodeficiency diseases or chemotherapy-induced immunosuppression, cryptosporidial enterocolitis may become chronic and have severe consequences.

Application Notes (Clone): This antibody reacts with both sporozoites and merozoites of C. parvum in an indirect immunofluorescence assay. This antibody is capable of neutralizing sporozoites and merozoites in a time dependent manner (PMID: 2193057; 2473130). This antibody can be used for the identification of sporozoites, merozoites and CPS-500 antigen of C. parvum using western blot. The identification of sporozoite-neutralizing antibody was done using ELISA (PMID: 20086143). This antibody in combination with PLA2 or LL37 was also used in the generation of a biocide fusion proteins to kill C. parvum sporozoites in vitro and in vivo (PMID: 20086143).
More Information
SKU ABAAb03424-21.0-BT
Manufacturer Absolute Antibody
Manufacturer SKU Ab03424-21.0-BT
Package Unit 500 μg
Quantity Unit STK
Reactivity Various species
Clonality Recombinant
Application Immunofluorescence, Western Blotting, ELISA, Electron microscopy (EM)
Isotype IgM kappa
Host Mouse
Product information (PDF) Download
MSDS (PDF) Download