Anti-CTLA-4 (NB25B-17)

Anti-CTLA-4 [NB25B-17], Recombinant, IgG-Fc Fusion, Rabbit

CloneID: NB25B-17

Antigen Long Description: The original antibody was generated by immunizing alpaca with human CTLA-4, followed by antibody library construction and phage display-based selection.

Buffer Composition: PBS only.

Uniprot Accession No.: P16410

Specificity Statement: The antibody is specific for CTLA-4. CTLA-4 is a protein receptor that functions as an immune checkpoint and downregulates immune responses.

Application Notes (Clone): The binding affinity of humanized VHH-Fc chimeric antibody to human CTLA-4 expressed in CHO cells was shown by FACS experiments. The blocking activity of the humanized VHH-Fc chimeric antibody to the binding of CTLA-4 to CD80 or CD86 was shown using FACS. The antitumor activity of the humanized antibody was demonstrated in vivo in animal models. Specifically, a tumor animal model was established by inoculating mice with human breast cancer cells MDA-MB-231 (ATCC) to induce breast cancer. Mice were grouped and administered with the humanized version of the antibody, and tumor volume in tumor-bearing animals was measured periodically in size. Results showed that the humanized version of the antibody was able to significantly reduce tumor volume in tumor-bearing mice (CN113121689).

• SKU: ABAAb03235-23.159-BT
• Manufacturer: Absolute Antibody
• Manufacturer SKU: Ab03235-23.159-BT
• Package Unit: 1 mg
• Quantity Unit: STK
• Reactivity: Human, Monkey (Primate)
• Clonality: Recombinant
• Application: In Vivo Assay, Fluorescence-Activated Cell Sorting (FACS)
• Isotype: IgG-Fc Fusion
• Host: Rabbit