CloneID: R1D3
Heavy Chain modification: Fc Silent™
Origin Pub PMID: 36378644
Buffer Composition: PBS only.
Chimeric Use Statement: This is a reformatted human IgG1 Fc Silent™ antibody, based on the original human IgG1 format, created for improved compatibility with existing reagents, assays and techniques.
Uniprot Accession No.: P62897
Specificity Statement: The antibody is specific for cytochrome c. The antibody binds to a variety of oxidatively modified cyt c species, such as nitrated at Tyr74 or oxidized at Met80, which lose the sixth heme ligation (Fe-Met80); it does not bind to several cyt c phospho- and acetyl-mimetics.
Application Notes (Clone): The antibody was employed to identify alternative conformations of cyt c in cells under oxidant- or senescence-induced challenge as confirmed by immunocytochemistry (Tomasina et al., 2022; PMID: 36378644).
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