CloneID: RCK106
Heavy Chain modification: Fc Silent™
Antigen Long Description: The original antibody was generated by immunizing a mouse with cytokeratins from the Human bladder carcinoma cell line T24.
Buffer Composition: PBS with 0.02% Proclin 300.
Chimeric Use Statement: This is a reformatted human IgG1 Fc Silent™ antibody, based on the original human IgG1 format, created for improved compatibility with existing reagents, assays and techniques.
Available Custom Conjugation Options: AP, HRP, Fluorescein, APC, PE, Biotin Type A, Biotin Type B, Streptavidin, FluoroProbes 647H, Atto488, APC/Cy7, PE/Cy7
Uniprot Accession No.: P05783
Specificity Statement: The antibody reacts exclusively with Cytokeratin 18 in glandular epithelial cells of the digestive, respiratory, and urogenital tracts, endocrine and exocrine cells and mesothelial cells, as well as adenocarcinomas originating from them.
Application Notes (Clone): The antibody detected Cytokeratin 18 by western blot analysis. The antibody reacted with endocervical columnar cells, cervical immature squamous metaplasia and CINIII by immunohistochemistry (Smedts et al., 1990; PMID: 1690513). The antibody stained transitional cell carcinomas of the urinary tract of different grade and stage (Schaafsma et al., 1990; PMID: 1689541).
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