CloneID: RCK108
Heavy Chain modification: Fc Silent™
Antigen Long Description: The original antibody was generated by immunizing mice with cell line T24.
Buffer Composition: PBS with 0.02% Proclin 300.
Chimeric Use Statement: This is a reformatted human IgG1 Fc Silent™ antibody, based on the original human IgG1 format, created for improved compatibility with existing reagents, assays and techniques.
Available Custom Conjugation Options: AP, HRP, Fluorescein, APC, PE, Biotin Type A, Biotin Type B, Streptavidin, FluoroProbes 647H, Atto488, APC/Cy7, PE/Cy7
Uniprot Accession No.: P08727
Specificity Statement: The antibody is specific for Cytokeratin 19. Cytokeratin 19 is found in most simple epithelia and non keratinized squamous epithelia with predominant focal reactivity.
Application Notes (Clone): The antibody could be used as a broad epithelial marker for carcinoma detection, due to its reproducible and highly sensitive staining. The antibody stained practically all epithelial tumours, especially adenocarcinoma, but it is negative in hepatocellular carcinoma (Kwaspen et al., 1997; PMID: 9447381). Antibody RCK108 reacts with a 40 kDa keratin (Cytokeratin 19) in immunoblot.
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