CloneID: 06CT8.1.1.1
Antigen Long Description: The original antibody was generated by immunizing BALB/c mice with DM1-cysteine-KLH conjugate.
Buffer Composition: PBS with 0.02% Proclin 300.
Available Custom Conjugation Options: AP, HRP, Fluorescein, APC, PE, Biotin Type A, Biotin Type B, Streptavidin, FluoroProbes 647H, Atto488, APC/Cy7, PE/Cy7
Specificity Statement: This antibody binds maytansine (DM1), a thiol-containing maytansinoid which is a highly potent microtubule-targeted compound that induces mitotic arrest and kills tumor cells at subnanomolar concentrations. The potent cell killing ability of maytansine can be used in a targeted delivery approach, such as an antibody-drug conjugate (ADC), for the selective delivery of the drug and destruction of cancer cells. ADCs with this design include trastuzumab emtansine, lorvotuzumab mertansine, and cantuzumab mertansine.
Application Notes (Clone): The binding reactivity of this antibody towards BSA-DM1 was determined using ELISA. This antibody is recommended for detection of antibody-drug conjugates containing DM1 (CN114276448).
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