CloneID: 06CT8.1.1.1
Heavy Chain modification: Fc Silent™
Antigen Long Description: The original antibody was generated by immunizing BALB/c mice with DM1-cysteine-KLH conjugate.
Buffer Composition: PBS only.
Chimeric Use Statement: This is a reformatted human IgG1 Fc Silent™ antibody, based on the original human IgG1 format, created for improved compatibility with existing reagents, assays and techniques.
Specificity Statement: This antibody binds maytansine (DM1), a thiol-containing maytansinoid which is a highly potent microtubule-targeted compound that induces mitotic arrest and kills tumor cells at subnanomolar concentrations. The potent cell killing ability of maytansine can be used in a targeted delivery approach, such as an antibody-drug conjugate (ADC), for the selective delivery of the drug and destruction of cancer cells. ADCs with this design include trastuzumab emtansine, lorvotuzumab mertansine, and cantuzumab mertansine.
Application Notes (Clone): The binding reactivity of this antibody towards BSA-DM1 was determined using ELISA. This antibody is recommended for detection of antibody-drug conjugates containing DM1 (CN114276448).
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