Anti-EGFR domain III (h-R3 (Nimotuzumab))

Anti-EGFR domain III [h-R3 (Nimotuzumab)], Recombinant, IgG kappa, Rabbit

CloneID: h-R3 (Nimotuzumab)

Antigen Long Description: This antibody we generated by humanisation of the murine antibody R3, raised against EGFR purified from placenta membranes and A431 tumors.

Origin Pub PMID: 9154469

Buffer Composition: PBS only.

Chimeric Use Statement: This chimeric rabbit antibody was made using the variable domain sequences of the original Human IgG1 format, for improved compatibility with existing reagents, assays and techniques.

Uniprot Accession No.: P00533

Specificity Statement: Binds to human EGFR domain III at a site distinct from antibody 7A7 (Ab00134) (Talavera et al. 2011)

Application Notes (Clone): This antibody binds to human EGFR and inhibits EGF-dependent clonogenic growth of NRK cells and completely blocks EGF stimulated autophosphorylation of the receptor (Fernandez 1992)

• SKU: ABAAb00723-23.0-BT
• Manufacturer: Absolute Antibody
• Manufacturer SKU: Ab00723-23.0-BT
• Package Unit: 1 mg
• Quantity Unit: STK
• Reactivity: Human
• Clonality: Recombinant
• Application: Flow Cytometry, Immunohistochemistry, Blocking
• Isotype: IgG kappa
• Host: Rabbit