CloneID: EGFR-8
Heavy Chain modification: Fc Silent™
Antigen Long Description: The original antibody was generated by immunizing BALB/c female mice with head and neck squamous carcinoma cell lines, such as CA922 (Japanese Collection of Research Bioresources (JCRB), Shinjuku, Japan) and HSC4 (JCRB, Shinjuku, Japan).
Buffer Composition: PBS with 0.02% Proclin 300.
Chimeric Use Statement: This is a reformatted human IgG1 Fc Silent™ antibody, based on the original human IgG1 format, created for improved compatibility with existing reagents, assays and techniques.
Available Custom Conjugation Options: AP, HRP, Fluorescein, APC, PE, Biotin Type A, Biotin Type B, Streptavidin, FluoroProbes 647H, Atto488, APC/Cy7, PE/Cy7
Uniprot Accession No.: P00533
Specificity Statement: The antibody is specific for EGFR.
Application Notes (Clone): The humanized version of the antibody exhibited strong specific binding to both human tumor cell lines and Vero cells by flow cytometry. Experiments showed the antibody is agonistic to EGFR (US20160017053A1).
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