CloneID: ITS090.03
Antigen Long Description: The original antibody was raised by immunizing a rhesus macaque with the well-characterized neutralization-resistant SIVmac239 strain
Buffer Composition: PBS only.
Uniprot Accession No.: E7CWP5
Specificity Statement: This antibody recognizes a highly glycosylated epitope on the gp120 core.
Application Notes (Clone): The original antibody was used for a virus neutralization assay on SIV Env pseudoviruses. This antibody shows its ability to neutralize this virus (Gorman et al., 2019; PMID:31586542). This antibody was used for an competitive ELISA on SIVmac239 SOSIP.664 (Zhao et al., 2022; PMID:36068229), and on SIVmac239 gp140 FT and SIVmac239 gp120 V1V2V3-deleted gp120 core proteins. The structure of the original antibody was determined using both electron microscopy and x-ray crystallography (Gorman et al., 2019; PMID:31586542) (Zhao et al., 2022; PMID:36068229).
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