Anti-Factor VIII (EL-16)

Anti-Factor VIII [EL-16], Recombinant, IgG kappa, Rabbit
SKU
ABAAb04010-23.0-BT
Packaging Unit
1 mg
Manufacturer
Absolute Antibody

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CloneID: EL-16

Antigen Long Description: The original antibody was isolated from a human phage display library generated from the peripheral blood of an inhibitor patient and panning the library against factor VIII light chain.

Buffer Composition: PBS only.

Uniprot Accession No.: P00451

Specificity Statement: This antibody binds the C2 domain of the human factor VIII, a glycoprotein involved in blood coagulation. Factor VIII acts as a cofactor for factor IXa which converts factor X to the activated form Xa in the presence of calcium and phospholipids. Defects in the F8 gene, which encodes Factor VIII, result in the coagulation disorder hemophilia A.

Application Notes (Clone): The inhibitory activity of this antibody against factor VIII was determined using a one-stage clotting assay. This antibody was capable of completely eliminating FVIII inhibition by CLB-CAg 117, a C2 domain directed anti-factor VIII antibody (PMID: 10627462).
More Information
SKU ABAAb04010-23.0-BT
Manufacturer Absolute Antibody
Manufacturer SKU Ab04010-23.0-BT
Package Unit 1 mg
Quantity Unit STK
Reactivity Human
Clonality Recombinant
Application Functional Assay, Inhibition
Isotype IgG kappa
Host Rabbit
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