Anti-Factor VIII (YK3.3.38)

Anti-Factor VIII [YK3.3.38], Recombinant, IgG kappa, Rabbit

CloneID: YK3.3.38

Antigen Long Description: The original antibody was isolated from a scFv phage display library generated using the peripheral blood lymphocytes from a hemophilia patient.

Buffer Composition: PBS only.

Uniprot Accession No.: P00451

Specificity Statement: This antibody is specific for an epitope 'RPLYSRRLPKGVKHLKDFPILPGEI' (residues 389 to 510) in the A2 domain of the human factor VIII, a glycoprotein involved in blood coagulation. Factor VIII acts as a cofactor for factor IXa which converts factor X to the activated form Xa in the presence of calcium and phospholipids. Defects in the F8 gene, which encodes Factor VIII, result in the coagulation disorder hemophilia A.

Application Notes (Clone): This antibody can bind human blood coagulation factor VIII in an ELISA. It was reported that this antibody potently inhibits the coagulation activity of factor VIII in vitro at a concentration of 10 ng/ml. This antibody does not inactivate FVIII bound with vWF but inactivated FVIII free from vWF (US20040120951).

• SKU: ABAAb03956-23.0-BT
• Manufacturer: Absolute Antibody
• Manufacturer SKU: Ab03956-23.0-BT
• Package Unit: 1 mg
• Quantity Unit: STK
• Reactivity: Human
• Clonality: Recombinant
• Application: ELISA
• Isotype: IgG kappa
• Host: Rabbit