CloneID: F11 (HSF102)
Heavy Chain modification: Fc Silent™
Antigen Long Description: The original antibody was generated by immunizing female Balb/c mice with ferritin extracted from human spleen cells.
Origin Pub PMID: 9891990
Buffer Composition: PBS with 0.02% Proclin 300.
Chimeric Use Statement: This is a reformatted human IgG1 Fc Silent™ antibody, based on the original human IgG2a format, created for improved compatibility with existing reagents, assays and techniques.
Available Custom Conjugation Options: AP, HRP, Fluorescein, APC, PE, Biotin Type A, Biotin Type B, Streptavidin, FluoroProbes 647H, Atto488, APC/Cy7, PE/Cy7
Uniprot Accession No.: Q8N4E7
Specificity Statement: This antibody binds human ferritin. This protein catalyzes the oxidation of ferrous iron(II) to ferric iron(III) and stores iron in a soluble, non-toxic, readily available form. Ferritin is important for iron homeostasis.
Application Notes (Clone): The binding characterization of this antibody towards human spleen ferritin was done using ELISA. This antibody was also reported to show binding affinity for protein A. Binding of this antibody to ferritin causes antigen-induced conformational changes in the antibody and reduces its affinity for protein A (PMID: 9776583).
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