CloneID: 3F10
Heavy Chain modification: Fc Silent™
Antigen Long Description: The original antibody was generated by immunizing mice with FLNB antigen.
Buffer Composition: PBS with 0.02% Proclin 300.
Chimeric Use Statement: This is a reformatted human IgG1 Fc Silent™ antibody, based on the original human IgG2a format, created for improved compatibility with existing reagents, assays and techniques.
Available Custom Conjugation Options: AP, HRP, Fluorescein, APC, PE, Biotin Type A, Biotin Type B, Streptavidin, FluoroProbes 647H, Atto488, APC/Cy7, PE/Cy7
Uniprot Accession No.: O75369
Specificity Statement: The antibody is specific for FLNB. FLNB is a cytoplasmic protein which in humans is encoded by the FLNB gene. FLNB regulates intracellular communication and signalling by cross-linking the protein actin to allow direct communication between the cell membrane and cytoskeletal network, to control and guide proper skeletal development.
Application Notes (Clone): The specificity of the original format of the antibody was confirmed by ELISA analysis. The binding kinetics of the antibody to the full length FLNA protein was measured by BLI (Kd= 1 nM) (WO2018085441A1).
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