CloneID: SE
Antigen Long Description: The original antibody was generated by screening human scFv antibody libraries.
Buffer Composition: PBS only.
Uniprot Accession No.: P08514
Specificity Statement: This antibody binds the glycoprotein GPIIb/IIIa complex (CD41/CD61 complex). The GPIIb/IIIa is a heterodimeric complex formed after synthesis of one lib and one Ilia subunit. The principal ligand for GPIIb/IIIa is fibrinogen, but it also binds to fibronectin, von Willebrand factor, vitronectin, thrombospondin and CD40 ligand. The binding between GPIIb/IIIa and fibrinogen dimers leads to platelet aggregation and thrombus formation, and this is possible only when the receptor adopts its activated conformation.
Application Notes (Clone): The antibody bound to activated platelets and inhibited platelet activation. This antibody was used for detection of activated platelets by flow cytometry (WO2020237304).
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