Anti-Gn (RV-Gn1)

Anti-Gn [RV-Gn1], Recombinant, IgG kappa, Rabbit

CloneID: RV-Gn1

Antigen Long Description: The original antibody was generated by immunizing New Zealand White rabbits with the full-length RVFV Gn ectodomain.

Buffer Composition: PBS only.

Uniprot Accession No.: P21401

Specificity Statement: The antibody is specific for the Gn protein. The antibody is directed to the membrane-distal domain of RVFV Gn.

Application Notes (Clone): The specificity of the original format of the antibody was confirmed by ELISA analysis.The antibody was able to able to neutralize RVFV in vitro. A plaque reduction neutralization test (PRNT) demonstrated that the antibody neutralized RVFV with half-maximal inhibitory concentration (IC50) values ranging from 2.1 to 3.0 μg/mL. The antibody protected against RVFV challenge in a murine infection model. The structure of rift valley fever virus Gn in complex with the Fab fragment of the antibody was determined, revealings that the antibody targeted to the membrane-distal head region of RVFV Gn (Allen et al., 2018; PMID: 30590046).

• SKU: ABAAb03696-23.0-BT
• Manufacturer: Absolute Antibody
• Manufacturer SKU: Ab03696-23.0-BT
• Package Unit: 1 mg
• Quantity Unit: STK
• Reactivity: Virus
• Clonality: Recombinant
• Application: ELISA, Neutralization, Crystallography, In Vivo Assay
• Isotype: IgG kappa
• Host: Rabbit