CloneID: F113-135
Heavy Chain modification: Fc Silent™
Antigen Long Description: A large number of B lymphocytes were collected from a donor, and a library was constructed using phage display technology. The original antibody was isolated by panning the library against HA-enriched fraction of virus particles.
Buffer Composition: PBS with 0.02% Proclin 300.
Chimeric Use Statement: This reformatted human antibody was made using the variable domain sequences of the original Human Fab format for improved compatibility with existing reagents assays and techniques.
Available Custom Conjugation Options: AP, HRP, Fluorescein, APC, PE, Biotin Type A, Biotin Type B, Streptavidin, FluoroProbes 647H, Atto488, APC/Cy7, PE/Cy7
Uniprot Accession No.: U6BPF8
Specificity Statement: The antibody is specific for HA and the epitope is located at the 150 loop of HA. The antibody The first bind to all Yamagata lineage viruses.
Application Notes (Clone): The specificity of the original format of the antibody was confirmed by ELISA analysis. The antibody detected the HA by western blot analysis. The original antibody bound to the surface of HA1-expressing cells. The original version of the antibody showed neutralizing activity by focus reduction assay (Hirano et al., 2018; PMID: 29854845).
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