CloneID: H85
Antigen Long Description: The Fab fragment was selected from a human combinatorial antibody library constructed in a phage-display vector by a panning procedure against an HSV lysate.
Buffer Composition: PBS with 0.02% Proclin 300.
Available Custom Conjugation Options: AP, HRP, Fluorescein, APC, PE, Biotin Type A, Biotin Type B, Streptavidin, FluoroProbes 647H, Atto488, APC/Cy7, PE/Cy7
Specificity Statement: The antibody binds to herpes simplex virus (HSV) antigens. The antibody is reactive with HSV-1 only.
Application Notes (Clone): The specificity of the original format of the antibody was confirmed by ELISA analysis. The Fab was able to specifically recognize Vero cells infected by HSV-1 in indirect immunofluorescence (IF) assays. The Fab was further evaluated as reagents for viral detection and typing by IF staining in 134 HSV-positive (72 HSV-1 and 62 HSV-2) viral cultures from clinical specimens, where it recognized the F (HSV-1) reference strain . The detection sensitivity with the Fab in indirect IF assays was higher overall than that provided by the type-specific murine monoclonal antibodies (Cattani et al., 1997; PMID:9163470).
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