CloneID: F17B1
Antigen Long Description: The original antibody was generated by immunizing male MRL/lpr mice with an an emulsion containing complete adjuvant H37Ra and purified sHLA-A-flag protein.
Buffer Composition: PBS with 0.02% Proclin 300.
Available Custom Conjugation Options: AP, HRP, Fluorescein, APC, PE, Biotin Type A, Biotin Type B, Streptavidin, FluoroProbes 647H, Atto488, APC/Cy7, PE/Cy7
Specificity Statement: The antibody is specific for HLA class I. The antibody binds to the following subclasses: A2, A3, A11, A23, A24, A25, A26, A29, A30, A31, A32, A33, A34, A68.
Application Notes (Clone): The original antibody showed strong cell death-inducing activity by FACS analysis. The antibody was used for detection of beads coated HLA class I antigen by flow cytometry. The human chimeric and the humanized version of the antibody was constructed. The human chimeric antibody was administered into a mouse model for human myeloma. The result showed that the antibody can significantly prolong the survival period of the mouse model for human myeloma.
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