Anti-HLA-G (9Y5G6)

Anti-HLA-G [9Y5G6], Recombinant, IgG1 kappa, Human

CloneID: 9Y5G6

Antigen Long Description: The original antibody was generated by immunizing BALB/c mice with synthetic human HLA-G molecule heavy chain amino acid sequence '229SKEGDGGIMSVRSLSED319'.

Buffer Composition: PBS only.

Uniprot Accession No.: P17693

Specificity Statement: This antibody specifically binds the amino acid sequence 'SKEGDGGIMSVRSLSED' of the human HLA-G5 and HLA-G6. HLA-G5 and HLA-G6 are secreted forms of HLA-G that are non-classical major histocompatibility class Ib molecules involved in immune regulatory processes at the maternal-fetal interface. HLA-G expression has been reported in numerous types of cancer, always associated with more advanced stage and aggressive development of the tumor.

Application Notes (Clone): This antibody can bind human HLA-G peptide 'KEGDGGIMSVRSLSED' in an ELISA with a binding affinity of Ka= 1.5 X 10^(11) L/mol. This antibody was capable of detecting G5 and G6 isoforms of human HLA-G in a western blot and does not cross react with any other isoforms of HLA-G. This antibody can also be used for the immunohistochemical detection of HLA-G5 and HLA-G6 molecules in different gastric cancer tissues using immunohistochemistry (CN113045656).

• SKU: ABAAb03657-10.0-BT
• Manufacturer: Absolute Antibody
• Manufacturer SKU: Ab03657-10.0-BT
• Package Unit: 1 mg
• Quantity Unit: STK
• Reactivity: Human
• Clonality: Recombinant
• Application: Western Blotting, ELISA, Immunohistochemistry
• Isotype: IgG1 kappa
• Host: Human