Bulk Anti-Human CD11a (38) Antibody

Bulk Anti-Human CD11a (38) Antibody, Host: Mouse, Mouse IgG2a

Target: CD11a

Clone: 38

Specificity: Anti-CD11a In Vivo Antibody - Low Endotoxin (38) recognizes Human CD11a. Anti-Human CD11a (Anti-LFA-1a) recognizes the (Mr 175 kDa) a chain of the leukocyte function associated antigen-1 (LFA-1). The leukocyte integrin LFA-1 is a member of a family of heterodimeric receptors that mediate divalent cation-dependent cellular adhesion reactions. LFA-1A binds to domain 1 of an intercellular adhesion molecule (ICAM) on target tissues.

Purification method: This monoclonal antibody was purified using Protein A

Antigen Distribution: The CD11a antigen is present on most leukocytes and plays a vital role in cellular immune responses which require adhesion. Lymphocyte activation via the T-cell antigen receptor (TCR) up-regulates LFA-1 function. The absence of LFA-1A or B may induce the disease state known as leukocyte adhesion deficiency (LAD). Tumor cells which do not express LFA-1 may have avoided cellular immune-responses such as those carried out by natural killer cells (NK).

Background: Anti-CD11a may be used to study a variety of biological phenomena related to the function of cell adhesion molecules. This antibody may be used to study transplantation rejections and to assist in characterizing lymphomas and leukemias.

Immunogen: Unknown

Concentration: 1.0 - 5.0 mg/ml

Formulation: 0.01 M phosphate buffered saline (PBS) pH 7.2, 150 mM NaCl with no carrier protein, potassium or preservatives added.

Purity: >95% by SDS-PAGE and HPLC

Endotoxin: ≤ 1.0 EU/mg as determined by the LAL method

Aggregation: Aggregation level ≤ 5%

Use: Products are for research use only. Not for use in diagnostic or therapeutic procedures.

• SKU: ICH1006-50MG
• Manufacturer: Ichorbio
• Manufacturer SKU: ICH1006-50MG
• Package Unit: 50mg
• Quantity Unit: STK
• Reactivity: Human
• Clonality: Monoclonal
• Application: Immunofluorescence, Immunohistochemistry (frozen), Immunoprecipitation, Western Blotting, Flow Cytometry
• Isotype: Mouse IgG2a
• Host: Mouse