Anti-IL-12/IL-23p40 (CNTO 1275 (Ustekinumab))

Anti-IL-12/IL-23p40 [CNTO 1275 (Ustekinumab)], Recombinant, IgG1 kappa, Human

CloneID: CNTO 1275 (Ustekinumab)

Antigen Long Description: The original antibody was produced by immunizing human immunoglobulin transgenic mice ((CBA/J×C57/BL6/J) F2 hybrid) with human recombinant IL-12.

Buffer Composition: PBS only.

Specificity Statement: This antibody is specific for the p40 subunit of human IL-12/23.

Application Notes (Clone): This antibody inhibits the interactions of IL-12 and IL-23 with the cell surface IL-12Rβ1 receptor and has been evaluated in phase I, II, and III trials as a treatment for immune-mediated diseases such as psoriasis, psoriatic arthritis, Crohn’s disease, multiple sclerosis, and ulcerative colitis (Elliott et al., 2009; PMID: 20074279) (Sands et al., 2019; PMID: 31553833).

• SKU: ABAAb04238-10.0-BT
• Manufacturer: Absolute Antibody
• Manufacturer SKU: Ab04238-10.0-BT
• Package Unit: 1 mg
• Quantity Unit: STK
• Reactivity: Human
• Clonality: Recombinant
• Application: Blocking, In Vivo Assay
• Isotype: IgG1 kappa
• Host: Human