Anti-IL-34 (FAb1.1)

Anti-IL-34 [FAb1.1], Recombinant, IgG1 kappa, Human

CloneID: FAb1.1

Antigen Long Description: The original antibody was generated by panning a Fab library against IL-34.

Buffer Composition: PBS only.

Uniprot Accession No.: Q6ZMJ4

Specificity Statement: The antibody is specific for human and murine IL-34. The antibody recognizes a largely continuous area at the junction of two IL-34 protomers. The epitope overlaps largely with binding epitopes responsible for CSF-1R binding.

Application Notes (Clone): The crystal structure of the Fab fragment of the antibody in complex with human IL-34 was determined. The original antibody was reformatted as an IgG molecules and the binding affinity of both formats measured by BLI experiments (Kd= 17 nM and 120 pM respectively). The antibody blocked the biological activity of IL-34 in human monocyte viability. The antibody neutralized IL-34 in a proliferation assays (Ma et al., 2012; PMID: 22483114).

• SKU: ABAAb03933-10.0-BT
• Manufacturer: Absolute Antibody
• Manufacturer SKU: Ab03933-10.0-BT
• Package Unit: 1 mg
• Quantity Unit: STK
• Reactivity: Human, Mouse (Murine)
• Clonality: Recombinant
• Application: Blocking, Neutralization
• Isotype: IgG1 kappa
• Host: Human