Anti-IL-4 (25D2-9)

Anti-IL-4 [25D2-9], Recombinant, IgG2b kappa, Mouse
SKU
ABAAb03715-3.0-BT
Packaging Unit
1 mg
Manufacturer
Absolute Antibody

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CloneID: 25D2-9

Antigen Long Description: The original antibody was generated by immunizing Lewis rat with 1ml of human IL-4. The humanized version of the antibody was created later by grafting CDRs from the original rat antibody onto human framework regions.

Buffer Composition: PBS only.

Uniprot Accession No.: P05112

Specificity Statement: This antibody binds human IL-4. Interleukin-4 is a cytokine secreted primarily by mast cells, T-cells, eosinophils, and basophils that plays a role in regulating antibody production, hematopoiesis and inflammation, and the development of effector T-cell responses. It induces differentiation of naive helper T cells (Th0 cells) to Th2 cells. It also induces expression of class II MHC molecules on resting B-cells and enhances both secretion and cell surface expression of IgE and IgG1.

Application Notes (Clone): The binding characterization of this antibody for human IL-4 was done using ELISA. This antibody was also capable of inhibiting binding of radiolabeled hIL-4 to recombinant hIL-4 receptors expressed on the Jijoye CJ cell line. This antibody was also reported to inhibit induction of human growth hormone in the germline epsilon reporter assay (US5597710; US5863537).
More Information
SKU ABAAb03715-3.0-BT
Manufacturer Absolute Antibody
Manufacturer SKU Ab03715-3.0-BT
Package Unit 1 mg
Quantity Unit STK
Reactivity Human
Clonality Recombinant
Application ELISA, Inhibition
Isotype IgG2b kappa
Host Mouse
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