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Application: Useful for binding assays.
Assay Conditions: Assay was performed according to IL-4RA: IL-4 [Biotinylated] Inhibitor Screening Chemiluminescence Assay Kit (#83532).
Background: Interleukin-4 (IL-4) is produced mainly by a subpopulation of activated T cells (Th2) that are the biologically most active helper cells for B cells and also secrete interleukin-5 (IL-5) and interleukin-6 (IL-6). The biological activities of IL-4 are mediated by a specific receptor. The extracellular domain of the IL-4 receptor is related to the receptors for EPO (erythropoietin), IL-6, and the beta chain of the IL-2 receptor (CD122). There are two types of receptors for IL-4. Type 1 receptor is a heterodimer consisting of IL-4Ralpha (IL-4Rα) and IL-4Rgamma (IL-4Rγc), mostly present on hematopoietic cells. The type 2 receptor is a heterodimer consisting of IL-4Ralpha and IL-13Ralpha1 (Il-13Rα1). IL-4 enhances the expression of MHC-2 (major histocompatibility class 2) antigens on B cells. It can promote their capacity to respond to other B cell stimuli and to present antigens for T cells. Pretreatment of macrophages with IL-4 prevents the production of IL-1, TNFα (tumor necrosis factor alpha), and prostaglandins in response to activation by bacterial endotoxins or IFN-γ (interferon gamma). IL-4 plays crucial roles in inflammation, fibrosis, allergic reactions, and cancer. The therapeutic exploitation of IL-4 signaling pathways may advance the treatment of auto-immune disorders
Description: Recombinant anti-IL-4Ra (interleukin 4 receptor subunit alpha) antibody recognizing human IL-4Ra protein, also known as CD124 (cluster of differentiation 124). This anti-IL-4Ra antibody is a purified, human recombinant monoclonal antibody, which contains an Avi-Tag™ at the C-terminus of the heavy chain unit. This antibody has been tested in a binding assay. It is similar to Dupilumab.
Format: Aqueous buffer solution.
Formulation: 8 mM phosphate, pH 7.4, 110 mM NaCl, 2.2 mM KCl, and 20% glycerol
Host Cell Line: HEK293
Purity: ≥85%
Storage Stability: At least 12 months at -80°C.
Tags: Avi-tag
Target: IL-4, IL-4Ra
Uniprot: P24394
Warnings: Avoid freeze/thaw cycles.
Biosafety Level: Not applicable (BSL-1)
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