CloneID: SB-240563 (Mepolizumab)
Antigen Long Description: The original antibody was generated by grafting of CDRs from mouse parental antibody 2B6 onto human framework regions. The parental mouse antibody 2B6 was generated by immunizing mice with recombinant human IL-5.
Buffer Composition: PBS only.
Uniprot Accession No.: P05113
Specificity Statement: This antibody recognizes and binds human interleukin-5, a key cytokine responsible for the differentiation, maturation, recruitment and activation of human eosinophils. This antibody does not cross react with mouse IL-5.
Application Notes (Clone): The pharmacokinetics of this antibody was investigated after intravenous and subcutaneous administration to cynomolgus monkeys. Suppression of eosinophil count was observed after multiple monthly administrations of this antibody to monkeys (PMID: 10565825). Pre-clinical efficacy and safety studies in cynomolgus monkeys demonstrated that chronic antagonism of IL-5 by mepolizumab is safe and has the potential to be beneficial therapy for chronic inflammatory respiratory diseases (PMID: 11496242). In a double-blind randomized placebo-controlled trial, the effects of treatment on responses to inhaled allergen challenge, sputum eosinophils, and airway hyper-responsiveness to histamine were measured at weeks 1 and 4 after a single intravenous infusion of this antibody. This antibody lowered the mean blood eosinophil count in placebo group and prevented the blood eosinophilia that follows allergen challenge. It also significantly reduced sputum eosinophilia seen after inhaled allergen challenge. It was further reported that this antibody had no significant effect to IL-5 on the late asthmatic response or on airway hyperresponsiveness to histamine (PMID: 11191542). In a double blind placebo-controlled study in asthmatic patients this antibody markedly reduced peripheral blood eosinophils without altering the distribution and activation status of lymphocytes (PMID: 12765424).
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