Anti-IL-8 (M36-11)

Anti-IL-8 [M36-11], Recombinant, IgG1 lambda, Mouse

CloneID: M36-11

Antigen Long Description: The original antibody 4-123-36 was isolated from a human single domain antibody (scFv) library by screening the library against extracellular portions of the human IL-8. Affinity maturation of this clone using mutagenesis by error-prone PCR resulted in the generation of M36-11.

Buffer Composition: PBS only.

Chimeric Use Statement: This chimeric mouse antibody was made using the variable domain sequences of the original Human IgG1 format for improved compatibility with existing reagents assays and techniques.

Uniprot Accession No.: P10145

Specificity Statement: This antibody binds human interleukin-8. Interleukin-8 is a chemotactic factor that attracts neutrophils, basophils, and T-cells, but not monocytes. It is also involved in neutrophil activation. It is released from several cell types in response to an inflammatory stimulus.

Application Notes (Clone): The binding of this affinity-maturated antibody to hIL8 was analyzed using ELISA. ​This antibody is capable of blocking the biological activity of human interleukin 8 at a concentration of 1 and 10 μg/mL in a neutrophil chemotaxis assay (PMID: 20718039).

• SKU: ABAAb03217-1.1-BT
• Manufacturer: Absolute Antibody
• Manufacturer SKU: Ab03217-1.1-BT
• Package Unit: 1 mg
• Quantity Unit: STK
• Reactivity: Human
• Clonality: Recombinant
• Application: ELISA, Blocking
• Isotype: IgG1 lambda
• Host: Mouse