Anti-IL23 (p19) (G23-8)

Anti-IL23 (p19) [G23-8], Recombinant, IgG2b kappa, Rat

CloneID: G23-8

Antigen Long Description: The original antibody was generated by immunizing rats with recombinant mouse IL-23 heterodimer.

Buffer Composition: PBS only.

Uniprot Accession No.: Q9EQ14

Specificity Statement: This antibody binds p19 subunit of mouse interleukin-23 (IL-23). IL-23A associates with IL-12B to form IL-23 interleukin which is a heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of pro-inflammatory cytokine IL-17. Mouse IL-23 also induces strong proliferation of memory T cells. IL-23 is secreted by activated dendritic cells.

Application Notes (Clone): This antibody can neutralize the bioactivity of IL-23 with no effect on IL-12 p70 bioactivity. This antibody can be used for the detection of mouse IL-23 p19 in an ELISA (PMID: 18802055). This antibody was used in assay to determine the effect of anti-IL23p19 antibody on increase in IL-17 production after neutralization of IL-4 in T cells cultured with IL-4 DCs or with non transduced DCs (PMID: 17195211). This antibody was reported to inhibit lactic acid-induced enhancement of IL-17 production by OT-II mouse splenocytes that had been stimulated with the TLR ligand peptidoglycan (PGN) and bacillus Calmette-Gue´rin cell wall skeleton (BCG-CWS) (PMID: 18490716).

• SKU: ABAAb03741-8.1-BT
• Manufacturer: Absolute Antibody
• Manufacturer SKU: Ab03741-8.1-BT
• Package Unit: 1 mg
• Quantity Unit: STK
• Reactivity: Mouse (Murine)
• Clonality: Recombinant
• Application: ELISA, Neutralization, Functional Assay
• Isotype: IgG2b kappa
• Host: Rat