CloneID: H116
Antigen Long Description: The original antibody was generated from a B lymphocyte islet-infiltrate of a diabetes-resistant but insulitis-prone (8.3-NODxNOR) F1 mouse.
Origin Pub PMID: 18433871
Buffer Composition: PBS with 0.02% Proclin 300.
Available Custom Conjugation Options: AP, HRP, Fluorescein, APC, PE, Biotin Type A, Biotin Type B, Streptavidin, FluoroProbes 647H, Atto488, APC/Cy7, PE/Cy7
Specificity Statement: This antibody is specific for an unknown autoantigen (still under investigation, as of 2016), expressed in islet beta cells (also referred to as intraislet).
Application Notes (Clone): This antibody recognizes antigenic determinants selectively expressed in islet β-cells of the pancreas, as determined by immunofluorescence (IF) staining; its staining pattern mimics the pattern obtained with anti-insulin antibodies. Furthermore, this antibody was shown to be cross-reactive with stomach and kidney cryosections of NOD.RAG-2−/− mice (Carrillo et al., 2005; PMID: 15616012). This antibody was also used for tissue immunostaining of pancreatic cryosections from NOD.RAG-2−/− mice (Carrascal et al., 2016; PMID: 26639224).
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