Anti-KRAS G12D mutant (D113)

Anti-KRAS G12D mutant [D113], Recombinant, IgG1 kappa, Human

CloneID: D113

Antigen Long Description: The original antibody was generated by immunizing mice with a synthetic dodecapeptide 'KLVVVGADGVGK'.

Buffer Composition: PBS only.

Uniprot Accession No.: P01116-2

Specificity Statement: This antibody binds the G12D mutant form of human KRAS protein. This ras protein binds GDP/GTP and possess intrinsic GTPase activity, that results in conversion of nucleotide guanosine triphosphate (GTP) into guanosine diphosphate (GDP). This protein plays an important role in many signal transduction pathways and regulation of cell proliferation. Somatic KRAS mutations are highly observed in leukemias, colorectal cancer, pancreatic cancer and lung cancer. KRAS mutation is G12D which is estimated to be present in up to 37% pancreatic cancers and over 12% of colorectal cancers.

Application Notes (Clone): The binding reactivity and epitope characterization of this antibody towards human KRAS G12D mutant was determined using ELISA (PMID: 9440050). This antibody can bind both the peptide 'KLVVVGADGVGK' conjugated BSA as well as KRAS G12D mutant in an ELISA.

• SKU: ABAAb03877-10.0-BT
• Manufacturer: Absolute Antibody
• Manufacturer SKU: Ab03877-10.0-BT
• Package Unit: 1 mg
• Quantity Unit: STK
• Reactivity: Human
• Clonality: Recombinant
• Application: ELISA
• Isotype: IgG1 kappa
• Host: Human