Anti-LAG-3 (209B1)

Anti-LAG-3 [209B1], Recombinant, IgG1 kappa, Human

CloneID: 209B1

Heavy Chain modification: Fc Silent™

Antigen Long Description: The original antibody was generated by immunizing female BALB/c mice with Flag-his-tagged extracellular domain of LAG-3.

Buffer Composition: PBS with 0.02% Proclin 300.

Chimeric Use Statement: This chimeric human antibody was made using the variable domain sequences of the original Mouse IgG4 format for improved compatibility with existing reagents assays and techniques.

Available Custom Conjugation Options: AP, HRP, Fluorescein, APC, PE, Biotin Type A, Biotin Type B, Streptavidin, FluoroProbes 647H, Atto488, APC/Cy7, PE/Cy7

Uniprot Accession No.: P18627

Specificity Statement: The antibody is specific for human LAG-3.

Application Notes (Clone): The antibody is a humanized version of the mouse antibody MAB209B1. The binding affinity of the antibody to hLAG-3 was measured by surface plasmon resonance. The binding affinity of this antibody towards human LAG-3 was found to be Kd= 7.7pM. The antibody showed a good tumour inhibitory effect in in vivo application (WO2021136392).

• SKU: ABAAb03508-10.3
• Manufacturer: Absolute Antibody
• Manufacturer SKU: Ab03508-10.3
• Package Unit: 100 μg
• Quantity Unit: STK
• Reactivity: Human
• Clonality: Recombinant
• Application: Surface Plasmon Resonance (SPR), Inhibition
• Isotype: IgG1 kappa
• Host: Human