CloneID: AbAbLAG3
Antigen Long Description: The original antibody was generated by immunizing transgenic HuMab or KM mice with recombinant human LAG-3 protein.
Buffer Composition: PBS with 0.02% Proclin 300.
Available Custom Conjugation Options: AP, HRP, Fluorescein, APC, PE, Biotin Type A, Biotin Type B, Streptavidin, FluoroProbes 647H, Atto488, APC/Cy7, PE/Cy7
Uniprot Accession No.: P18627
Specificity Statement: The antibody is specific for LAG3. Lymphocyte activation gene 3 protein is an inhibitory receptor on antigen activated T-cells. It delivers inhibitory signals upon binding to ligands, such as FGL1.
Application Notes (Clone): The binding characterization of this antibody to human LAG3-Fc fusion protein was done using ELISA. The original human IgG antibody was reported to bind human LAG-3 in the sub picomolar range. This antibody was effective in inhibiting the binding of LAG3 to MHC class II molecules in an in vitro binding assay. In the antigen-specific T cell response assay, this antibody can stimulate the production of IL-2 (CN109748963).
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