CloneID: 100
Heavy Chain modification: Fc Silent™
Antigen Long Description: The original format of the antibody was generated by immunizing transgenic mice with human M-CSF.
Buffer Composition: PBS only.
Chimeric Use Statement: This is a reformatted human IgG1 Fc Silent™ antibody, based on the original human IgG1 format, created for improved compatibility with existing reagents, assays and techniques.
Uniprot Accession No.: P09603
Specificity Statement: The antibody is specific for M-CSF.
Application Notes (Clone): The original format of the antibody inhibited mouse monocytic cell proliferation in response to M-CSF. Further, the IC50 for inhibition of mouse nonocytic cell proliferation was determined for the antibody (IC50 = 15.3 nM). The binding properties of the original format of the antibody were analyzed using SPR analysis (Kd= 0.2 pM) (US7326414B2).
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